产品货号：
Z18916
中文名称：
IKAP/IKBKAP抗体
英文名称：
Anti-IKAP/IKBKAP Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IKAP/IKBKAP Antibody |
| 指标别名 | FD,DYS,ELP1,IKAP,IKI3,TOT1,Elongator complex protein 1,IkappaB kinase complex-associated protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | IKBKAP |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | IKAP antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human IKAP.The immunogen is located within the last 50 amino acids of IKAP. |
| 计算分子量 | 150kDa |
| 成分 | IKAP Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | IKAP Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | IKAP was initially identified as a scaffold protein of the I百B kinase complex that could bind to IKK汐，IKK汕，NF-百B,and the NF-百B-inducing kinase (NIK),although later evidence has cast doubt on this.More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD).Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation.More recently,it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1,indicating another possible cause for FD. |
| Uniprot ID | O95163 |
| 基因名全称 | Inhibitor of kappa light polypeptide gene enhancer in B-cells,kinase complex-associated protein |
| 蛋白名全称 | Inhibitor of kappa light polypeptide gene enhancer in B-cells,kinase complex-associated protein |
| 推荐稀释比 | IKAP antibody can be used for detection of IKAP by Western blot at 0.5 to 1μg/mL.Antibody can also be used for immunocytochemistry starting at 1μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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